Thomas Reinheckel Selected Research

Peptide Hydrolases (Proteases)

1/2022	RNA interference screens discover proteases as synthetic lethal partners of PI3K inhibition in breast cancer cells.
1/2021	The secreted inhibitor of invasive cell growth CREG1 is negatively regulated by cathepsin proteases.
1/2021	A 9-kDa matricellular SPARC fragment released by cathepsin D exhibits pro-tumor activity in the triple-negative breast cancer microenvironment.
1/2021	Analyzing the Role of Proteases in Breast Cancer Progression and Metastasis Using Primary Cells from Transgenic Oncomice.
10/2020	Cathepsin D deficiency in mammary epithelium transiently stalls breast cancer by interference with mTORC1 signaling.
7/2020	Conditional Gene Targeting Reveals Cell Type-Specific Roles of the Lysosomal Protease Cathepsin L in Mammary Tumor Progression.
5/2020	Early trypsin activation develops independently of autophagy in caerulein-induced pancreatitis in mice.
1/2020	Tumor cell- and microenvironment-specific roles of cysteine cathepsins in mouse models of human cancers.
11/2019	Impact of proteolysis on cancer stem cell functions.
1/2019	The role of proteases in epithelial-to-mesenchymal cell transitions in cancer.

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Thomas Reinheckel Research Topics

Disease

36	Neoplasms (Cancer) 01/2022 - 03/2006
16	Breast Neoplasms (Breast Cancer) 01/2022 - 05/2006
13	Neoplasm Metastasis (Metastasis) 01/2021 - 05/2006
7	Carcinogenesis 01/2018 - 03/2006
6	Inflammation (Inflammations) 01/2016 - 03/2008
5	Alopecia (Baldness) 10/2017 - 12/2004
5	Infections 10/2015 - 10/2010
4	Alzheimer Disease (Alzheimer's Disease) 01/2022 - 08/2008
4	Pancreatitis 05/2020 - 02/2010
4	Proteinuria 01/2018 - 05/2011
4	Fibrosis (Cirrhosis) 01/2018 - 06/2006
3	Ischemia 01/2022 - 02/2005
3	Tics (Tic) 11/2019 - 09/2016
3	Arthritis (Polyarthritis) 12/2013 - 11/2011
3	Hyperplasia 05/2011 - 12/2004
3	Dilated Cardiomyopathy (Cardiomyopathy, Congestive) 12/2007 - 04/2002
2	Multiple Sclerosis 01/2022 - 10/2017
2	Frontotemporal Lobar Degeneration (Degeneration, Frontotemporal Lobar) 01/2022 - 01/2017
2	Pain (Aches) 01/2022 - 01/2016
2	Stroke (Strokes) 01/2022 - 01/2016
2	Hypoxia (Hypoxemia) 08/2021 - 12/2003
2	Graft vs Host Disease (Graft-Versus-Host Disease) 12/2020 - 01/2017
2	Colorectal Neoplasms (Colorectal Cancer) 01/2018 - 01/2015
2	Kidney Diseases (Kidney Disease) 01/2018 - 10/2011
2	Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental) 10/2017 - 01/2017
2	Lysosomal Storage Diseases (Lysosomal Storage Disease) 01/2017 - 11/2003
2	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2017 - 03/2012
2	Neuronal Ceroid-Lipofuscinoses (Neuronal Ceroid Lipofuscinosis) 03/2016 - 10/2012
2	Metaplasia 01/2016 - 01/2013
2	Pancreatic Neoplasms (Pancreatic Cancer) 01/2016 - 06/2012
2	Wounds and Injuries (Trauma) 10/2014 - 05/2009
2	Rheumatoid Arthritis 09/2012 - 01/2007
2	Renal Insufficiency (Renal Failure) 03/2012 - 10/2011
2	Cardiomyopathies (Cardiomyopathy) 08/2010 - 06/2006
1	Periodontitis 01/2022
1	Traumatic Brain Injuries (Traumatic Brain Injury) 01/2022
1	Nervous System Diseases (Neurological Disorders) 01/2022
1	Cognitive Dysfunction 01/2022
1	Brain Diseases (Brain Disorder) 01/2022
1	Epilepsy (Aura) 01/2022
1	Atrophy 08/2021
1	Triple Negative Breast Neoplasms 01/2021
1	Intestinal Neoplasms (Intestinal Cancer) 01/2020
1	Contact Dermatitis (Eczema, Contact) 01/2019
1	Psoriasis (Pustulosis Palmaris et Plantaris) 01/2019

Drug/Important Bio-Agent (IBA)

32	Peptide Hydrolases (Proteases)FDA Link 01/2022 - 04/2002
20	CathepsinsIBA 01/2021 - 03/2006
16	Cathepsin BIBA 01/2022 - 03/2006
16	Cathepsin LIBA 07/2020 - 04/2002
15	Cysteine (L-Cysteine)FDA Link 12/2020 - 04/2002
14	Cysteine Proteases (Cysteine Protease)IBA 11/2019 - 12/2004
12	Proteins (Proteins, Gene)FDA Link 01/2018 - 05/2009
9	EnzymesIBA 01/2022 - 03/2006
6	Cathepsin DIBA 01/2021 - 03/2008
5	ProteomeIBA 01/2018 - 02/2015
4	Pharmaceutical PreparationsIBA 01/2022 - 02/2009
4	CeruletideIBA 05/2020 - 02/2010
4	Cathepsin ZIBA 10/2017 - 02/2010
3	Cathepsin HIBA 08/2021 - 08/2010
3	Cathepsin CIBA 12/2020 - 03/2006
3	TrypsinogenIBA 05/2020 - 02/2010
3	Biological ProductsIBA 11/2019 - 01/2012
3	Cathepsin KIBA 11/2019 - 09/2006
3	CollagenIBA 01/2018 - 08/2008
3	Peptides (Polypeptides)IBA 01/2017 - 08/2008
3	Protease Inhibitors (Protease Inhibitor)IBA 09/2016 - 10/2010
2	ProgranulinsIBA 01/2022 - 01/2017
2	Biomarkers (Surrogate Marker)IBA 01/2022 - 01/2016
2	Mechanistic Target of Rapamycin Complex 1IBA 10/2020 - 04/2017
2	TrypsinIBA 05/2020 - 02/2010
2	Matrix Metalloproteinases (MMPs)IBA 11/2019 - 01/2015
2	Serine (L-Serine)FDA Link 11/2019 - 10/2013
2	Metalloproteases (Metalloproteinases)IBA 11/2019 - 01/2019
2	Messenger RNA (mRNA)IBA 01/2018 - 06/2015
2	Cathepsin EIBA 01/2017 - 01/2012
2	RNA (Ribonucleic Acid)IBA 01/2017 - 09/2016
2	CD2-associated proteinIBA 11/2016 - 10/2011
2	Dynamins (Dynamin)IBA 11/2016 - 10/2011
2	CytokinesIBA 02/2011 - 10/2010
2	ChemokinesIBA 02/2011 - 08/2010
2	Interleukin-6 (Interleukin 6)IBA 02/2011 - 01/2002
2	Amyloid beta-PeptidesIBA 08/2009 - 08/2008
2	Cadherins (E-Cadherin)IBA 05/2009 - 03/2006
1	GranulinsIBA 01/2022
1	Opiate AlkaloidsIBA 01/2022
1	cathepsin SIBA 01/2022
1	Hematoxylin (Haematoxylon)IBA 08/2021
1	Eosine Yellowish-(YS) (Eosin)IBA 08/2021
1	Conditioned Culture MediaIBA 01/2021
1	Detergents (Detergent)IBA 12/2020
1	Cystatin BIBA 12/2020
1	leucyl-leucine-methyl esterIBA 12/2020
1	Amino Acids FDA Link 07/2020
1	Amylases FDA Link 05/2020
1	ProdrugsIBA 01/2020
1	Granzymes (Granzyme)IBA 11/2019
1	Phenobarbital (Luminal)FDA Link 01/2019

Therapy/Procedure

7	Therapeutics 01/2022 - 01/2007
3	Transplantation 01/2021 - 01/2011
3	Drug Therapy (Chemotherapy) 11/2019 - 11/2009